Glucocorticoid Receptor Expression Profiles in Mononuclear Leukocytes of Periparturient Holstein Cows

Glucocorticoid receptor expression profiles in mononuclear leukocytes of periparturient Holstein cows.

Cortisol-activated glucocorticoid receptors modulate cellular responses to stress by translocating from the cytosol to the nucleus and enhancing or repressing the transcription of target genes. The functional capacity of mononuclear leukocytes is inhibited in parturient dairy cows at a time when blood cortisol concentrations are high. Because the glucocorticoid receptor is autoregulatory in man...

Changes in serum electrolytes of holstein cows with periparturient diseases

Changes in some Blood Micronutrients, Leukocytes and Neutrophil Expression of Adhesion Molecules in Periparturient Dairy Cows

Dairy cows are highly susceptible to infectious diseases, like mastitis, during the period around calving. Although factors contributing to increased susceptibility to infection have not been fully elucidated, impaired neutrophil recruitment to the site of infection and changes in the concentrations of some micronutrients related with the function of the immune defence has been implicated. Most...

Blood metabolic profiles in Uruguayan Holstein and Uruguayan Holstein x New Zealand Holstein-Friesian dairy cows

Blood metabolic profiles were determined from 40 days prepartum to 60 days postpartum in Uruguayan Holstein (UH) (n = 13) and UH x New Zealand Holstein-Friesian first cross (UH-NZHF) (n = 13) cows with seven in each group experiencing their second lactation (L2) and six experiencing their third lactation (L3). Non-esterified fatty acids increased around calving and tended to be greater in UH-L3...

Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis.

The number and affinity of glucocorticoid binding sites in peripheral mononuclear leukocytes of patients with atopic dermatitis (AD) and healthy controls were determined under baseline conditions and after a defined oral glucocorticoid treatment. Patients with AD (n = 15) exhibited significantly more glucocorticoid receptors (GR) per cell than the control group (n = 22), while the GR affinity d...